MGP Database

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MGP001920

Ontology/Pathway Information

Entrez Gene ID4257
Gene Namemicrosomal glutathione S-transferase 1
Gene Symbol MGST1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0005783 ISS:UniProtKBCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 ISS:UniProtKBCintegral component of membrane
GO:0005743 IEA:EnsemblCmitochondrial inner membrane
GO:0005741 IEA:UniProtKB-SubCellCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005634 IEA:EnsemblCnucleus
GO:0005778 ISS:UniProtKBCperoxisomal membrane
GO:0043295 IEA:EnsemblFglutathione binding
GO:0004602 IDA:UniProtKBFglutathione peroxidase activity
GO:0004364 IDA:UniProtKBFglutathione transferase activity
GO:0071449 IDA:UniProtKBPcellular response to lipid hydroperoxide
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0006749 IEA:EnsemblPglutathione metabolic process
GO:0033327 IEA:EnsemblPLeydig cell differentiation
GO:0055114 IDA:UniProtKBPoxidation-reduction process
GO:0070207 ISS:UniProtKBPprotein homotrimerization
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0010243 IEA:EnsemblPresponse to organonitrogen compound
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264461Aflatoxin activation and detoxification
REACT_13433Biological oxidations
REACT_267633Defective ACY1 causes encephalopathy
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_6959Phase II conjugation
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