MGP Database

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MGP001921

UniProt Annotations

Entry Information
Gene Namemicrosomal glutathione S-transferase 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99735-1; Sequence=Displayed; Name=2; IsoId=Q99735-2; Sequence=VSP_044538; Note=No experimental confirmation available.;
Catalytic ActivityRX + glutathione = HX + R-S-glutathione.
FunctionCan catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitHomotrimer.
Tissue SpecificityLiver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mgst2/";
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