MGP Database

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MGP001988

Ontology/Pathway Information

Entrez Gene ID4597
Gene Namemevalonate (diphospho) decarboxylase
Gene Symbol MVD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004163 IDA:UniProtKBFdiphosphomevalonate decarboxylase activity
GO:0030544 IPI:UniProtKBFHsp70 protein binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0006695 NAS:UniProtKBPcholesterol biosynthetic process
GO:0006488 TAS:ReactomePdolichol-linked oligosaccharide biosynthetic process
GO:0006489 TAS:ReactomePdolichyl diphosphate biosynthetic process
GO:0019287 IEA:InterProPisopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299 IDA:UniProtKBPisoprenoid biosynthetic process
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0018279 TAS:ReactomePprotein N-linked glycosylation via asparagine
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_22426Asparagine N-linked glycosylation
REACT_22433Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACT_9405Cholesterol biosynthesis
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_22230Synthesis of Dolichyl-phosphate
REACT_22387Synthesis of substrates in N-glycan biosythesis
SMP Pathway Links
SMP IDDescription
SMP00095Alendronate Action Pathway
SMP00131Atorvastatin Action Pathway
SMP00111Cerivastatin Action Pathway
SMP00387CHILD Syndrome
SMP00508Cholesteryl ester storage disease
SMP00388Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
SMP00386Desmosterolosis
SMP00119Fluvastatin Action Pathway
SMP00209Hypercholesterolemia
SMP00509Hyper-IgD syndrome
SMP00079Ibandronate Action Pathway
SMP00099Lovastatin Action Pathway
SMP00319Lysosomal Acid Lipase Deficiency (Wolman Disease)
SMP00510Mevalonic aciduria
SMP00117Pamidronate Action Pathway
SMP00089Pravastatin Action Pathway
SMP00112Risedronate Action Pathway
SMP00092Rosuvastatin Action Pathway
SMP00082Simvastatin Action Pathway
SMP00389Smith-Lemli-Opitz Syndrome (SLOS)
SMP00023Steroid Biosynthesis
SMP00511Wolman disease
SMP00107Zoledronate Action Pathway
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