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MGP001988

UniProt Annotations

Entry Information
Gene Namemevalonate (diphospho) decarboxylase
Protein EntryMVD1_HUMAN
UniProt IDP53602
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate {ECO:0000269|PubMed:9392419}; KM=0.32 mM for ATP {ECO:0000269|PubMed:9392419};
Catalytic ActivityATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2). {ECO:0000269|PubMed:8626466}.
FunctionPerforms the first committed step in the biosynthesis of isoprenes.
PathwaySteroid biosynthesis; cholesterol biosynthesis.
SimilarityBelongs to the diphosphomevalonate decarboxylase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:8626466}.
Tissue SpecificityExpressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta. {ECO:0000269|PubMed:8626466}.
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