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MGP002037

Record overview

MGPD IDMGP002037
Gene ID4690
SpeciesHomo sapiens (Human)
Gene NameNCK adaptor protein 1
Gene Symbol NCK1
SynonymsNCK; nck-1; NCKalpha;
Alternate namescytoplasmic protein NCK1; NCK tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha; melanoma NCK protein; non-catalytic region of tyrosine kinase;
Chromosome3
Map Location3q21
SummaryThe protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for NCK1

Proteins

cytoplasmic protein NCK1 isoform 1
Refseq ID:NP_006144
Protein GI:5453754
UniProt ID:P16333
mRNA ID:NM_006153
Length:377
RefSeq Status:
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDP
GERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYP
FSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERG
HEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
 
cytoplasmic protein NCK1 isoform 1
Refseq ID:NP_001278928
Protein GI:635172876
UniProt ID:P16333
mRNA ID:NM_001291999
Length:377
RefSeq Status:
Protein sequence is identical to GI:5453754 (mRNA isoform)
 
cytoplasmic protein NCK1 isoform 2
Refseq ID:NP_001177725
Protein GI:299829184
UniProt ID:P16333
mRNA ID:NM_001190796
Length:313
RefSeq Status:
MDWLNVFKDFFSIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEG
DSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPP
QCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTS
EQGEKLYLVKHLS
 
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