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MGP002037

UniProt Annotations

Entry Information
Gene NameNCK adaptor protein 1
Protein EntryNCK1_HUMAN
UniProt IDP16333
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16333-1; Sequence=Displayed; Name=2; IsoId=P16333-2; Sequence=VSP_043122; Note=No experimental confirmation available.;
DomainOnly the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seeem to be involved.
FunctionAdapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
InteractionQ9H222:ABCG5; NbExp=2; IntAct=EBI-389883, EBI-1761423; P00519:ABL1; NbExp=2; IntAct=EBI-389883, EBI-375543; P42684:ABL2; NbExp=4; IntAct=EBI-389883, EBI-1102694; Q15109:AGER; NbExp=2; IntAct=EBI-389883, EBI-1646426; O43918:AIRE; NbExp=2; IntAct=EBI-389883, EBI-1753081; O15085:ARHGEF11; NbExp=3; IntAct=EBI-389883, EBI-311099; Q9ULH1:ASAP1; NbExp=6; IntAct=EBI-389883, EBI-346622; Q96NS5:ASB16; NbExp=2; IntAct=EBI-389883, EBI-1751918; Q9UIF9:BAZ2A; NbExp=2; IntAct=EBI-389883, EBI-934890; O60885:BRD4; NbExp=2; IntAct=EBI-389883, EBI-723869; Q9ULD4:BRPF3; NbExp=3; IntAct=EBI-389883, EBI-1753470; P13671:C6; NbExp=2; IntAct=EBI-389883, EBI-1753221; P20810:CAST; NbExp=2; IntAct=EBI-389883, EBI-1268770; Q13191:CBLB; NbExp=4; IntAct=EBI-389883, EBI-744027; P20963:CD247; NbExp=2; IntAct=EBI-389883, EBI-1165705; P07766:CD3E; NbExp=6; IntAct=EBI-389883, EBI-1211297; P30260:CDC27; NbExp=3; IntAct=EBI-389883, EBI-994813; Q9NYQ7:CELSR3; NbExp=2; IntAct=EBI-389883, EBI-308417; Q13111:CHAF1A; NbExp=2; IntAct=EBI-389883, EBI-1020839; Q14008:CKAP5; NbExp=3; IntAct=EBI-389883, EBI-310585; P78357:CNTNAP1; NbExp=2; IntAct=EBI-389883, EBI-1751903; P78329:CYP4F2; NbExp=2; IntAct=EBI-389883, EBI-1752413; P98082:DAB2; NbExp=2; IntAct=EBI-389883, EBI-1171238; Q14118:DAG1; NbExp=2; IntAct=EBI-389883, EBI-1755945; O14490:DLGAP1; NbExp=4; IntAct=EBI-389883, EBI-1753207; Q9P1A6:DLGAP2; NbExp=4; IntAct=EBI-389883, EBI-1753397; O95886:DLGAP3; NbExp=2; IntAct=EBI-389883, EBI-1752541; Q9Y2H0:DLGAP4; NbExp=5; IntAct=EBI-389883, EBI-722139; Q92988:DLX4; NbExp=3; IntAct=EBI-389883, EBI-1752755; Q05193:DNM1; NbExp=2; IntAct=EBI-389883, EBI-713135; Q8IZD9:DOCK3; NbExp=3; IntAct=EBI-389883, EBI-1752361; Q9H1R2:DUSP15; NbExp=2; IntAct=EBI-389883, EBI-1752795; Q9H8V3:ECT2; NbExp=3; IntAct=EBI-389883, EBI-1054039; P00533:EGFR; NbExp=3; IntAct=EBI-389883, EBI-297353; P41970:ELK3; NbExp=3; IntAct=EBI-389883, EBI-1758534; P42566:EPS15; NbExp=2; IntAct=EBI-389883, EBI-396684; O00254:F2RL2; NbExp=2; IntAct=EBI-389883, EBI-1751853; Q9BQ89:FAM110A; NbExp=2; IntAct=EBI-389883, EBI-1752811; P31994:FCGR2B; NbExp=2; IntAct=EBI-389883, EBI-724784; P31995:FCGR2C; NbExp=2; IntAct=EBI-389883, EBI-1396036; O75369:FLNB; NbExp=3; IntAct=EBI-389883, EBI-352089; O75593:FOXH1; NbExp=2; IntAct=EBI-389883, EBI-1759806; O15117:FYB; NbExp=3; IntAct=EBI-389883, EBI-1753267; Q13480:GAB1; NbExp=3; IntAct=EBI-389883, EBI-517684; Q9UBS5:GABBR1; NbExp=3; IntAct=EBI-389883, EBI-724156; Q99259:GAD1; NbExp=2; IntAct=EBI-389883, EBI-743184; P10912:GHR; NbExp=3; IntAct=EBI-389883, EBI-286316; Q9NZM4:GLTSCR1; NbExp=3; IntAct=EBI-389883, EBI-1754943; P15586:GNS; NbExp=2; IntAct=EBI-389883, EBI-1752200; O43708:GSTZ1; NbExp=2; IntAct=EBI-389883, EBI-748043; P10412:HIST1H1E; NbExp=2; IntAct=EBI-389883, EBI-358163; O43390:HNRNPR; NbExp=2; IntAct=EBI-389883, EBI-713419; P47928:ID4; NbExp=3; IntAct=EBI-389883, EBI-1754719; Q9H9L3:ISG20L2; NbExp=2; IntAct=EBI-389883, EBI-751335; O60674:JAK2; NbExp=2; IntAct=EBI-389883, EBI-518647; P35968:KDR; NbExp=3; IntAct=EBI-389883, EBI-1005487; P10721:KIT; NbExp=3; IntAct=EBI-389883, EBI-1379503; Q9UMN6:KMT2B; NbExp=2; IntAct=EBI-389883, EBI-765774; Q13094:LCP2; NbExp=14; IntAct=EBI-389883, EBI-346946; Q9BY71:LRRC3; NbExp=2; IntAct=EBI-389883, EBI-1761329; P27816:MAP4; NbExp=2; IntAct=EBI-389883, EBI-715255; Q92918:MAP4K1; NbExp=4; IntAct=EBI-389883, EBI-881; Q9Y4K4:MAP4K5; NbExp=2; IntAct=EBI-389883, EBI-1279; Q9NQ76:MEPE; NbExp=3; IntAct=EBI-389883, EBI-1753293; P08581:MET; NbExp=2; IntAct=EBI-389883, EBI-1039152; Q15746:MYLK; NbExp=2; IntAct=EBI-389883, EBI-968482; Q8WX92:NELFB; NbExp=6; IntAct=EBI-389883, EBI-347721; P43699:NKX2-1; NbExp=2; IntAct=EBI-389883, EBI-1391923; O60500:NPHS1; NbExp=3; IntAct=EBI-389883, EBI-996920; Q13177:PAK2; NbExp=2; IntAct=EBI-389883, EBI-1045887; Q13087:PDIA2; NbExp=3; IntAct=EBI-389883, EBI-1752525; O75167:PHACTR2; NbExp=2; IntAct=EBI-389883, EBI-1754409; O00750:PIK3C2B; NbExp=3; IntAct=EBI-389883, EBI-641107; Q9UL42:PNMA2; NbExp=2; IntAct=EBI-389883, EBI-302355; Q9BXM0:PRX; NbExp=2; IntAct=EBI-389883, EBI-1753064; P29074:PTPN4; NbExp=3; IntAct=EBI-389883, EBI-710431; P15918:RAG1; NbExp=2; IntAct=EBI-389883, EBI-1755109; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-389883, EBI-976876; P20936:RASA1; NbExp=6; IntAct=EBI-389883, EBI-1026476; Q9UQ26:RIMS2; NbExp=2; IntAct=EBI-389883, EBI-1756749; Q8TB24:RIN3; NbExp=2; IntAct=EBI-389883, EBI-1570523; P26373:RPL13; NbExp=2; IntAct=EBI-389883, EBI-356849; P78345:RPP38; NbExp=2; IntAct=EBI-389883, EBI-366493; P10301:RRAS; NbExp=3; IntAct=EBI-389883, EBI-968703; Q96GP6:SCARF2; NbExp=2; IntAct=EBI-389883, EBI-1752088; O75326:SEMA7A; NbExp=2; IntAct=EBI-389883, EBI-1753538; Q9NZV5:SEPN1; NbExp=2; IntAct=EBI-389883, EBI-1751965; Q9UPX8:SHANK2; NbExp=6; IntAct=EBI-389883, EBI-1570571; Q9BYB0:SHANK3; NbExp=4; IntAct=EBI-389883, EBI-1752330; Q13796:SHROOM2; NbExp=2; IntAct=EBI-389883, EBI-1644065; Q9UHI7:SLC23A1; NbExp=2; IntAct=EBI-389883, EBI-1759386; O60721:SLC24A1; NbExp=3; IntAct=EBI-389883, EBI-1753504; Q9UMY4:SNX12; NbExp=3; IntAct=EBI-389883, EBI-1752602; Q15036:SNX17; NbExp=3; IntAct=EBI-389883, EBI-1752620; Q9Y5X2:SNX8; NbExp=2; IntAct=EBI-389883, EBI-1752557; Q07889:SOS1; NbExp=5; IntAct=EBI-389883, EBI-297487; Q07890:SOS2; NbExp=3; IntAct=EBI-389883, EBI-298181; P08047:SP1; NbExp=2; IntAct=EBI-389883, EBI-298336; Q96T58:SPEN; NbExp=3; IntAct=EBI-389883, EBI-765739; Q9H5I1:SUV39H2; NbExp=2; IntAct=EBI-389883, EBI-723127; O15056:SYNJ2; NbExp=3; IntAct=EBI-389883, EBI-310513; O43493:TGOLN2; NbExp=3; IntAct=EBI-389883, EBI-1752146; P42167:TMPO; NbExp=2; IntAct=EBI-389883, EBI-455283; Q15661:TPSAB1; NbExp=2; IntAct=EBI-389883, EBI-1761369; Q9ULW0:TPX2; NbExp=4; IntAct=EBI-389883, EBI-1037322; Q9BWF2:TRAIP; NbExp=3; IntAct=EBI-389883, EBI-1756205; Q9HCM9:TRIM39; NbExp=2; IntAct=EBI-389883, EBI-739510; O00294:TULP1; NbExp=2; IntAct=EBI-389883, EBI-1756778; Q96RL7:VPS13A; NbExp=3; IntAct=EBI-389883, EBI-1752583; O43516:WIPF1; NbExp=2; IntAct=EBI-389883, EBI-346356;
PtmPhosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:1333046, ECO:0000269|PubMed:1448108, ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:7692233}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 3 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
SubunitInteracts (via SH2 domain and SH3 domain 2) with EGFR. Interacts with PAK1 and SOS1. Interacts (via SH3 domains) with PKN2. Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interacts with FASLG. Directly interacts with RASA1. Interacts with isoform 4 of MINK1. Interacts with FLT1 (tyrosine phosphorylated). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion. Interacts with EPHA2. Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated). Interacts with the inactive form of EIF2AK2/PKR. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:12091389, ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18269246, ECO:0000269|PubMed:18296648, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:21664272, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:9344857, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9600074, ECO:0000269|PubMed:9697839}.
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