MGP Database

MGP002105

Ontology/Pathway Information

Entrez Gene ID	4831
Gene Name	NME/NM23 nucleoside diphosphate kinase 2
Gene Symbol	NME2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0071944	IDA:UniProtKB	C	cell periphery
GO:0005813	IEA:Ensembl	C	centrosome
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IBA:GO_Central	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005882	IEA:Ensembl	C	intermediate filament
GO:0030027	IDA:HGNC	C	lamellipodium
GO:0016020	IEA:Ensembl	C	membrane
GO:0005739	IBA:GO_Central	C	mitochondrion
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0001726	IDA:HGNC	C	ruffle
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0004550	IDA:UniProtKB	F	nucleoside diphosphate kinase activity
GO:0004673	IEA:UniProtKB-EC	F	protein histidine kinase activity
GO:0000977	IEA:Ensembl	F	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700	TAS:UniProtKB	F	sequence-specific DNA binding transcription factor activity
GO:0003697	IEA:Ensembl	F	single-stranded DNA binding
GO:0007155	TAS:HGNC	P	cell adhesion
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0071398	IEA:Ensembl	P	cellular response to fatty acid
GO:0071333	IEA:Ensembl	P	cellular response to glucose stimulus
GO:0006241	IEA:InterPro	P	CTP biosynthetic process
GO:0006183	IEA:InterPro	P	GTP biosynthetic process
GO:0021766	IEA:Ensembl	P	hippocampus development
GO:0007229	IDA:UniProtKB	P	integrin-mediated signaling pathway
GO:0043066	IMP:HGNC	P	negative regulation of apoptotic process
GO:0010629	IEA:Ensembl	P	negative regulation of gene expression
GO:0002762	IEA:Ensembl	P	negative regulation of myeloid leukocyte differentiation
GO:0015949	TAS:Reactome	P	nucleobase-containing small molecule interconversion
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0009142	IDA:UniProtKB	P	nucleoside triphosphate biosynthetic process
GO:0050679	IMP:HGNC	P	positive regulation of epithelial cell proliferation
GO:0045618	IMP:HGNC	P	positive regulation of keratinocyte differentiation
GO:0010976	IEA:Ensembl	P	positive regulation of neuron projection development
GO:0045944	IDA:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0006163	IBA:GO_Central	P	purine nucleotide metabolic process
GO:0006220	IBA:GO_Central	P	pyrimidine nucleotide metabolic process
GO:0045682	IMP:HGNC	P	regulation of epidermis development
GO:0006355	TAS:UniProtKB	P	regulation of transcription, DNA-templated
GO:0014075	IEA:Ensembl	P	response to amine
GO:0051591	IEA:Ensembl	P	response to cAMP
GO:0033574	IEA:Ensembl	P	response to testosterone
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated
GO:0006228	IEA:InterPro	P	UTP biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_1698	Metabolism of nucleotides
REACT_21330	Synthesis and interconversion of nucleotide di- and triphosphates

SMP Pathway Links

SMP ID	Description
SMP00629	Adefovir Dipivoxil Metabolism Pathway
SMP00579	Congenital disorder of glycosylation CDG-IId
SMP00580	GLUT-1 deficiency syndrome
SMP00444	Lactose Synthesis
SMP00630	Tenofovir Metabolism Pathway