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MGP002105

UniProt Annotations

Entry Information
Gene NameNME/NM23 nucleoside diphosphate kinase 2
Protein EntryNDKB_HUMAN
UniProt IDP22392
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NM23-H2; IsoId=P22392-1; Sequence=Displayed; Name=3; Synonyms=NM23-LV; IsoId=P22392-2; Sequence=VSP_036708; Note=Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein. Initiator Met-1 is removed (By similarity). Contains a N-acetylalanine at position 2 (By similarity). {ECO:0000250};
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Catalytic ActivityATP + protein L-histidine = ADP + protein N- phospho-L-histidine.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionMajor role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}.
InteractionO14713-1:ITGB1BP1; NbExp=7; IntAct=EBI-713693, EBI-2127367; P15531:NME1; NbExp=2; IntAct=EBI-713693, EBI-741141;
SimilarityBelongs to the NDK family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
SubunitHexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region). {ECO:0000250, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:1851158}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:16442775}.
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