MGP Database

MGP002224

Record overview

MGPD ID	MGP002224
Gene ID	5154
Species	Homo sapiens (Human)
Gene Name	platelet-derived growth factor alpha polypeptide
Gene Symbol	PDGFA
Synonyms	PDGF1; PDGF-A;
Alternate names	platelet-derived growth factor subunit A; PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein;
Chromosome	7
Map Location	7p22
Summary	The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for PDGFA

Proteins

platelet-derived growth factor subunit A isoform 1 preproprotein

Refseq ID:	NP_002598
Protein GI:	77695917
UniProt ID:	P04085
mRNA ID:	NM_002607
Length:	211
RefSeq Status:

`MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRT VIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESG KKRKRKRLKPT`

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2132
peptide sequence: 
MRTLACLLLLGCGYLAHVLA

mat_peptide: 87..211
product: platelet-derived growth factor subunit A isoform 1
calculated_mol_wt: 14306
peptide sequence: 
SIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNP
DYREEDTGRPRESGKKRKRKRLKPT

platelet-derived growth factor subunit A isoform 2 preproprotein

Refseq ID:	NP_148983
Protein GI:	15208656
UniProt ID:	P04085
mRNA ID:	NM_033023
Length:	196
RefSeq Status:

`MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRT VIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTDVR`

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2132
peptide sequence: 
MRTLACLLLLGCGYLAHVLA

mat_peptide: 87..211
product: platelet-derived growth factor subunit A isoform 1
calculated_mol_wt: 14306
peptide sequence: 
SIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNP
DYREEDTGRPRESGKKRKRKRLKPT

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2132
peptide sequence: 
MRTLACLLLLGCGYLAHVLA

mat_peptide: 87..196
product: platelet-derived growth factor subunit A isoform 2
calculated_mol_wt: 12515
peptide sequence: 
SIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNP
DYREEDTDVR