MGP Database

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MGP002224

UniProt Annotations

Entry Information
Gene Nameplatelet-derived growth factor alpha polypeptide
Protein EntryPDGFA_HUMAN
UniProt IDP04085
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P04085-1; Sequence=Displayed; Name=Short; IsoId=P04085-2; Sequence=VSP_004602, VSP_004603;
DomainThe long form contains a basic insert which acts as a cell retention signal.
FunctionGrowth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.
InteractionP16234:PDGFRA; NbExp=6; IntAct=EBI-2881386, EBI-2861522;
SimilarityBelongs to the PDGF/VEGF growth factor family. {ECO:0000305}.
Subcellular LocationSecreted. Note=Released by platelets upon wounding.
SubunitHomodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4. {ECO:0000269|PubMed:10358027, ECO:0000269|PubMed:20534510}.
Web ResourceName=R&D Systems' cytokine mini-reviews: PDGF; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1967";
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