MGP Database

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MGP002224

Ontology/Pathway Information

Entrez Gene ID5154
Gene Nameplatelet-derived growth factor alpha polypeptide
Gene Symbol PDGFA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0005902 ISS:UniProtKBCmicrovillus
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005518 IDA:MGIFcollagen binding
GO:0008083 IDA:UniProtKBFgrowth factor activity
GO:0048407 IPI:BHF-UCLFplatelet-derived growth factor binding
GO:0005161 IDA:BHF-UCLFplatelet-derived growth factor receptor binding
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0042803 IDA:BHF-UCLFprotein homodimerization activity
GO:0030036 ISS:UniProtKBPactin cytoskeleton organization
GO:0001525 ISS:UniProtKBPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0001775 TAS:BHF-UCLPcell activation
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0030031 ISS:UniProtKBPcell projection assembly
GO:1990401 ISS:BHF-UCLPembryonic lung development
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0001942 ISS:UniProtKBPhair follicle development
GO:0045087 TAS:ReactomePinnate immune response
GO:0048839 IEA:EnsemblPinner ear development
GO:0048286 ISS:UniProtKBPlung alveolus development
GO:0050919 IDA:BHF-UCLPnegative chemotaxis
GO:0010512 IDA:BHF-UCLPnegative regulation of phosphatidylinositol biosynthetic process
GO:0010544 IDA:BHF-UCLPnegative regulation of platelet activation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 ISS:UniProtKBPorgan morphogenesis
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0048008 IDA:BHF-UCLPplatelet-derived growth factor receptor signaling pathway
GO:0051781 IEA:UniProtKB-KWPpositive regulation of cell division
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0045740 IDA:BHF-UCLPpositive regulation of DNA replication
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0048146 IDA:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0043410 IMP:UniProtKBPpositive regulation of MAPK cascade
GO:0043406 IDA:UniProtKBPpositive regulation of MAP kinase activity
GO:0002053 ISS:UniProtKBPpositive regulation of mesenchymal cell proliferation
GO:0035793 IDA:UniProtKBPpositive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0014068 IDA:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0031954 IDA:UniProtKBPpositive regulation of protein autophosphorylation
GO:0051897 IDA:UniProtKBPpositive regulation of protein kinase B signaling
GO:0032956 TAS:BHF-UCLPregulation of actin cytoskeleton organization
GO:0060683 ISS:UniProtKBPregulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0050730 ISS:UniProtKBPregulation of peptidyl-tyrosine phosphorylation
GO:0014910 IDA:BHF-UCLPregulation of smooth muscle cell migration
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0010035 IEA:EnsemblPresponse to inorganic substance
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0009611 IDA:BHF-UCLPresponse to wounding
GO:0043588 ISS:UniProtKBPskin development
GO:0007179 IEA:EnsemblPtransforming growth factor beta receptor signaling pathway
GO:0042060 TAS:BHF-UCLPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118779Extracellular matrix organization
REACT_163874Non-integrin membrane-ECM interactions
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
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