MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002251

Record overview

MGPD IDMGP002251
Gene ID5207
SpeciesHomo sapiens (Human)
Gene Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene Symbol PFKFB1
SynonymsF6PK; HL2K; PFRX;
Alternate names6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase;
ChromosomeX
Map LocationXp11.21
EC Number2.7.1.105
SummaryThis gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for PFKFB1

Proteins

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1
Refseq ID:NP_002616
Protein GI:118582286
UniProt ID:P16118
mRNA ID:NM_002625
Length:471
RefSeq Status:
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNME
ALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECY
EVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCL
LAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
Refseq ID:NP_001258733
Protein GI:424036667
UniProt ID:P16118
mRNA ID:NM_001271804
Length:449
RefSeq Status:
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKDNMEALQIRKQCALAALKDVHNYLSH
EEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFD
VGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQ
WKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTV
LKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
Refseq ID:NP_001258734
Protein GI:424036676
UniProt ID:P16118
mRNA ID:NM_001271805
Length:406
RefSeq Status:
MEEKTSRIKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPG
IIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELN
IRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKG
ESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALD
TVPAHY
 
  logo