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MGP002251

UniProt Annotations

Entry Information
Gene Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Protein EntryF261_HUMAN
UniProt IDP16118
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16118-1; Sequence=Displayed; Name=2; IsoId=P16118-2; Sequence=VSP_054795;
Catalytic ActivityATP + D-fructose 6-phosphate = ADP + beta-D- fructose 2,6-bisphosphate.
Catalytic ActivityBeta-D-fructose 2,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate.
Enzyme RegulationPhosphorylation at Ser-33 inhibits the kinase and activates the bisphosphatase. {ECO:0000250}.
FunctionSynthesis and degradation of fructose 2,6-bisphosphate.
InteractionP35557:GCK; NbExp=2; IntAct=EBI-709807, EBI-709928;
SimilarityIn the C-terminal section; belongs to the phosphoglycerate mutase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:12379646}.
Tissue SpecificityLiver.
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