MGP Database

MGP002251

Ontology/Pathway Information

Entrez Gene ID	5207
Gene Name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene Symbol	PFKFB1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0043540	IDA:UniProtKB	C	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
GO:0005829	TAS:Reactome	C	cytosol
GO:0003873	TAS:UniProtKB	F	6-phosphofructo-2-kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004331	IDA:UniProtKB	F	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0070095	IEA:Ensembl	F	fructose-6-phosphate binding
GO:0005975	TAS:Reactome	P	carbohydrate metabolic process
GO:0016311	IDA:GOC	P	dephosphorylation
GO:0006112	TAS:Reactome	P	energy reserve metabolic process
GO:0006003	IDA:UniProtKB	P	fructose 2,6-bisphosphate metabolic process
GO:0006000	IEA:InterPro	P	fructose metabolic process
GO:0006094	TAS:UniProtKB	P	gluconeogenesis
GO:0006006	TAS:Reactome	P	glucose metabolic process
GO:0006096	TAS:UniProtKB	P	glycolytic process
GO:0035556	TAS:Reactome	P	intracellular signal transduction
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0033133	IEA:Ensembl	P	positive regulation of glucokinase activity
GO:0051591	IEA:Ensembl	P	response to cAMP
GO:0033762	IEA:Ensembl	P	response to glucagon
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_116125	Disease
REACT_1520	Gluconeogenesis
REACT_723	Glucose metabolism
REACT_264090	Glycogen storage diseases
REACT_1383	Glycolysis
REACT_1505	Integration of energy metabolism
REACT_111217	Metabolism
REACT_474	Metabolism of carbohydrates
REACT_264430	Myoclonic epilepsy of Lafora
REACT_1525	PKA-mediated phosphorylation of key metabolic factors
REACT_705	PP2A-mediated dephosphorylation of key metabolic factors

SMP Pathway Links

SMP ID	Description
SMP00064	Fructose and Mannose Degradation
SMP00725	Fructose intolerance, hereditary
SMP00561	Fructosuria