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MGP002259

UniProt Annotations

Entry Information
Gene Nameprofilin 2
Protein EntryPROF2_HUMAN
UniProt IDP35080
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=IIa; IsoId=P35080-1; Sequence=Displayed; Name=IIb; IsoId=P35080-2; Sequence=VSP_005217;
FunctionBinds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
InteractionQ14789:GOLGB1; NbExp=2; IntAct=EBI-473138, EBI-709973; P42858:HTT; NbExp=4; IntAct=EBI-473138, EBI-466029; O08816:Wasl (xeno); NbExp=3; IntAct=EBI-473138, EBI-6142604;
SimilarityBelongs to the profilin family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton.
SubunitOccurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Tissue SpecificityHighly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
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