MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002306

Record overview

MGPD IDMGP002306
Gene ID5319
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group IB (pancreas)
Gene Symbol PLA2G1B
SynonymsPLA2; PLA2A; PPLA2;
Alternate namesphospholipase A2; phosphatidylcholine 2-acylhydrolase 1B;
Chromosome12
Map Location12q24.31
EC Number3.1.1.4
SummaryThis gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for PLA2G1B

Proteins

phospholipase A2 precursor
Refseq ID:NP_000919
Protein GI:4505847
UniProt ID:P04054
mRNA ID:NM_000928
Length:148
RefSeq Status:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCS
GSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
 
sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1526
peptide sequence: 
MKLLVLAVLLTVAAA

mat_peptide: 23..148
product: Phospholipase A2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P04054.3)
calculated_mol_wt: 14139
peptide sequence: 
AVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDR
NAAICFSKAPYNKAHKNLDTKKYCQS
 
  logo