MGP Database

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MGP002306

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IB (pancreas)
Protein EntryPA21B_HUMAN
UniProt IDP04054
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269|PubMed:19297324}.
PtmActivated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:19297324}. Note=secreted from pancreatic acinar cells in its inactive form.
SubunitMonomer or homodimer (By similarity). The inactive pro- form is a homotrimer. {ECO:0000250, ECO:0000269|PubMed:19297324}.
Web ResourceName=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/pla2g1b/";
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