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MGP002307

Record overview

MGPD IDMGP002307
Gene ID5320
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group IIA (platelets, synovial fluid)
Gene Symbol PLA2G2A
SynonymsMOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2;
Alternate namesphospholipase A2, membrane associated; GIIC sPLA2; NPS-PLA2; group IIA phospholipase A2; non-pancreatic secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A;
Chromosome1
Map Location1p35
EC Number3.1.1.4
SummaryThe protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for PLA2G2A

Proteins

phospholipase A2, membrane associated precursor
Refseq ID:NP_001155199
Protein GI:239915985
UniProt ID:P14555
mRNA ID:NM_001161727
Length:144
RefSeq Status:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQ
DSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
 
sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
 
phospholipase A2, membrane associated precursor
Refseq ID:NP_001155201
Protein GI:239915991
UniProt ID:P14555
mRNA ID:NM_001161729
Length:144
RefSeq Status:
Protein sequence is identical to GI:239915985 (mRNA isoform)
 
sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
 
phospholipase A2, membrane associated precursor
Refseq ID:NP_001155200
Protein GI:239915987
UniProt ID:P14555
mRNA ID:NM_001161728
Length:144
RefSeq Status:
Protein sequence is identical to GI:239915985 (mRNA isoform)
 
sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC

sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
 
phospholipase A2, membrane associated precursor
Refseq ID:NP_000291
Protein GI:4505849
UniProt ID:P14555
mRNA ID:NM_000300
Length:144
RefSeq Status:
Protein sequence is identical to GI:239915985 (mRNA isoform)
 
sig_peptide: 1..20
calculated_mol_wt: 2183
peptide sequence: 
MKTLLLLAVIMIFGLLQAHG

mat_peptide: 21..144
product: phospholipase A2, membrane associated
calculated_mol_wt: 13918
peptide sequence: 
NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
 
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