MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002307

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIA (platelets, synovial fluid)
Protein EntryPA2GA_HUMAN
UniProt IDP14555
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
FunctionThought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
MiscellaneousGroup II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationMembrane; Peripheral membrane protein.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLA2G2AID41730ch1p36.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g2a/";
  logo