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MGP002461

Record overview

MGPD IDMGP002461
Gene ID5645
SpeciesHomo sapiens (Human)
Gene Nameprotease, serine, 2 (trypsin 2)
Gene Symbol PRSS2
SynonymsTRY2; TRY8; TRYP2;
Alternate namestrypsin-2; anionic trypsinogen; protease serine 2 preproprotein; trypsin II; trypsinogen 2;
Chromosome7
Map Location7q34
EC Number3.4.21.4
SummaryThis gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
OrthologsView orthologs and multiple alignments for PRSS2

Proteins

trypsin-2 isoform 1 preproprotein
Refseq ID:NP_001290343
Protein GI:744066875
UniProt ID:
mRNA ID:NM_001303414
Length:261
RefSeq Status:
MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQ
FINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCV
GFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS
 
sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1560
peptide sequence: 
MNLLLILTFVAAAVA
 
trypsin-2 isoform 2 preproprotein
Refseq ID:NP_002761
Protein GI:4506147
UniProt ID:P07478
mRNA ID:NM_002770
Length:247
RefSeq Status:
MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYN
SRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDS
GGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS
 
sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1560
peptide sequence: 
MNLLLILTFVAAAVA

sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1560
peptide sequence: 
MNLLLILTFVAAAVA

mat_peptide: 24..247
product: Trypsin-2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P07478.1)
calculated_mol_wt: 24042
peptide sequence: 
IVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRV
SAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQK
NRPGVYTKVYNYVDWIKDTIAANS
 
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