MGP Database

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MGP002461

UniProt Annotations

Entry Information
Gene Nameprotease, serine, 2 (trypsin 2)
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPreferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionIn the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269|PubMed:12021776}.
PolymorphismHis-153 variation is a common polymorphism in African populations with a minor allele frequency of 9.2%, it eliminates sulfation at Tyr-154, with no consequences on digestive physiology. {ECO:0000269|PubMed:18986305}.
PtmSulfated on tyrosine. {ECO:0000269|PubMed:17087724}.
PtmSulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. {ECO:0000269|PubMed:25010489}.
SimilarityBelongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Subcellular LocationSecreted, extracellular space.
Tissue SpecificityExpressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}.
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