MGP Database

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MGP002519

Ontology/Pathway Information

Entrez Gene ID5739
Gene Nameprostaglandin I2 (prostacyclin) receptor (IP)
Gene Symbol PTGIR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:BHF-UCLCcytosol
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0004930 IEA:UniProtKB-KWFG-protein coupled receptor activity
GO:0005085 TAS:ReactomeFguanyl-nucleotide exchange factor activity
GO:0007189 IMP:BHF-UCLPadenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0007187 TAS:ProtIncPG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0010642 ISS:BHF-UCLPnegative regulation of platelet-derived growth factor receptor signaling pathway
GO:0048662 IDA:BHF-UCLPnegative regulation of smooth muscle cell proliferation
GO:0030819 IMP:BHF-UCLPpositive regulation of cAMP biosynthetic process
GO:0043950 IMP:BHF-UCLPpositive regulation of cAMP-mediated signaling
GO:0043547 TAS:GOCPpositive regulation of GTPase activity
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_18352Eicosanoid ligand-binding receptors
REACT_19327G alpha (s) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_604Hemostasis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_23876Platelet homeostasis
REACT_23946Prostacyclin signalling through prostacyclin receptor
REACT_18425Prostanoid ligand receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00354Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
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