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MGP002519

UniProt Annotations

Entry Information
Gene Nameprostaglandin I2 (prostacyclin) receptor (IP)
Protein EntryPI2R_HUMAN
UniProt IDP43119
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
PtmIsoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. {ECO:0000269|PubMed:11895442}.
PtmPalmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling. {ECO:0000269|PubMed:12488443}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts (non-isoprenylated C-terminus) with PDZK1. {ECO:0000250}.
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