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MGP002579

Record overview

MGPD IDMGP002579
Gene ID5906
SpeciesHomo sapiens (Human)
Gene NameRAP1A, member of RAS oncogene family
Gene Symbol RAP1A
SynonymsRAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21;
Alternate namesras-related protein Rap-1A; GTP-binding protein smg p21A; Ras-related protein Krev-1;
Chromosome1
Map Location1p13.3
SummaryThis gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
OrthologsView orthologs and multiple alignments for RAP1A

Proteins

ras-related protein Rap-1A precursor
Refseq ID:NP_002875
Protein GI:4506413
UniProt ID:P62834
mRNA ID:NM_002884
Length:184
RefSeq Status:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
 
mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC

mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC
 
ras-related protein Rap-1A precursor
Refseq ID:NP_001278825
Protein GI:631226406
UniProt ID:P62834
mRNA ID:NM_001291896
Length:184
RefSeq Status:
Protein sequence is identical to GI:4506413 (mRNA isoform)
 
mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC
 
ras-related protein Rap-1A precursor
Refseq ID:NP_001010935
Protein GI:58331202
UniProt ID:P62834
mRNA ID:NM_001010935
Length:184
RefSeq Status:
Protein sequence is identical to GI:4506413 (mRNA isoform)
 
mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC

mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC

mat_peptide: 1..181
product: Ras-related protein Rap-1A
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P62834.1)
calculated_mol_wt: 20648
peptide sequence: 
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQI
LRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSC
 
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