MGP Database

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MGP002579

UniProt Annotations

Entry Information
Gene NameRAP1A, member of RAS oncogene family
Protein EntryRAP1A_HUMAN
UniProt IDP62834
SpeciesHuman
Comments
Comment typeDescription
Enzyme RegulationActivated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
FunctionInduces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
InteractionP04049:RAF1; NbExp=2; IntAct=EBI-491414, EBI-365996; Q8WWW0-2:RASSF5; NbExp=3; IntAct=EBI-491414, EBI-960502; Q5EBH1:Rassf5 (xeno); NbExp=2; IntAct=EBI-491414, EBI-960530;
Sequence CautionSequence=CAB55685.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the small GTPase superfamily. Ras family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
SubunitFound in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain). {ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:11022048, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12444546, ECO:0000269|PubMed:17509819, ECO:0000269|PubMed:17704304, ECO:0000269|PubMed:17916086}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAP1AID272.html";
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