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MGP Database

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MGP002619

UniProt Annotations

Entry Information

Gene Name	regulator of G-protein signaling 2
Protein Entry	RGS2_HUMAN
UniProt ID	P41220
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative initiation; Named isoforms=4; Name=1; IsoId=P41220-1; Sequence=Displayed; Name=2; IsoId=P41220-2; Sequence=VSP_041296; Name=3; IsoId=P41220-3; Sequence=VSP_041297; Note=Lacks type V adenylyl cyclase (AC) inhibitory function.; Name=4; IsoId=P41220-4; Sequence=VSP_041298; Note=Lacks type V adenylyl cyclase (AC) inhibitory function.;
Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. {ECO:0000269\|PubMed:11278586, ECO:0000269\|PubMed:17901199, ECO:0000269\|PubMed:19736320, ECO:0000269\|PubMed:7643615}.
Interaction	Q5S007:LRRK2; NbExp=6; IntAct=EBI-712388, EBI-5323863; Q9ULJ8:PPP1R9A; NbExp=3; IntAct=EBI-712388, EBI-2515561;
Ptm	Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. {ECO:0000269\|PubMed:11063746, ECO:0000269\|PubMed:14608379}.
Similarity	Contains 1 RGS domain. {ECO:0000255\|PROSITE- ProRule:PRU00171}.
Subcellular Location	Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Subcellular Location	Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Subcellular Location	Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Subcellular Location	Isoform 4: Cell membrane. Mitochondrion.
Subunit	Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha). {ECO:0000269\|PubMed:14608379, ECO:0000269\|PubMed:19736320}.
Tissue Specificity	Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). {ECO:0000269\|PubMed:7643615}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RGS2ID42102ch1q31.html";