MGP Database

MGP002625

Record overview

MGPD IDMGP002625
Gene ID6009
SpeciesHomo sapiens (Human)
Gene NameRas homolog enriched in brain
Gene Symbol RHEB
SynonymsRHEB2;
Alternate namesGTP-binding protein Rheb; Ras homolog enriched in brain 2;
Chromosome7
Map Location7q36
SummaryThis gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RHEB

Proteins

GTP-binding protein Rheb
Refseq ID:NP_005605
Protein GI:5032041
UniProt ID:Q15382
mRNA ID:NM_005614
Length:184
RefSeq Status:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIH
GKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
 
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