MGP Database

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MGP002625

UniProt Annotations

Entry Information
Gene NameRas homolog enriched in brain
Protein EntryRHEB_HUMAN
UniProt IDQ15382
SpeciesHuman
Comments
Comment typeDescription
Enzyme RegulationAlternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2.
FunctionActivates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.
InteractionO43924:PDE6D; NbExp=5; IntAct=EBI-6860739, EBI-712685;
MiscellaneousThe conserved catalytic Gln-64 found in other Ras- like GTPases seems not to be involved in GTP hydrolysis in RHEB. {ECO:0000305}.
PtmFarnesylation is important for efficiently activating mTORC1- mediated signaling.
PtmPhosphorylation by MAPKAPK5 impairs GTP-binding and inactivation. {ECO:0000250|UniProtKB:Q921J2}.
SimilarityBelongs to the small GTPase superfamily. Rheb family. {ECO:0000305}.
Subcellular LocationEndomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}.
SubunitBinds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes. {ECO:0000269|PubMed:15728574, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:22002721}.
Tissue SpecificityUbiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269|PubMed:8543055}.
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