MGP Database

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MGP002625

Ontology/Pathway Information

Entrez Gene ID6009
Gene NameRas homolog enriched in brain
Gene Symbol RHEB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 IEA:EnsemblCdendrite
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 TAS:ProtIncCmembrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005886 IEA:UniProtKB-SubCellCplasma membrane
GO:0005681 IEA:EnsemblCspliceosomal complex
GO:0019003 IEA:EnsemblFGDP binding
GO:0003924 TAS:ProtIncFGTPase activity
GO:0005525 ISS:UniProtKBFGTP binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0007050 TAS:ReactomePcell cycle arrest
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0032008 IMP:UniProtKBPpositive regulation of TOR signaling
GO:0007165 TAS:ProtIncPsignal transduction
GO:0007264 IEA:InterProPsmall GTPase mediated signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_150210IGF1R signaling cascade
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_6964mTORC1-mediated signalling
REACT_6838mTOR signalling
REACT_976PI3K Cascade
REACT_456PKB-mediated events
REACT_21393Regulation of Rheb GTPase activity by AMPK
REACT_6836Release of eIF4E
REACT_6754S6K1-mediated signalling
REACT_498Signaling by Insulin receptor
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00682Leucine Stimulation on Insulin Signaling
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