MGP Database

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MGP002778

Ontology/Pathway Information

Entrez Gene ID6352
Gene Namechemokine (C-C motif) ligand 5
Gene Symbol CCL5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:EnsemblCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IEA:UniProtKB-KWCextracellular space
GO:0031726 IPI:UniProtKBFCCR1 chemokine receptor binding
GO:0031729 TAS:BHF-UCLFCCR4 chemokine receptor binding
GO:0031730 IPI:BHF-UCLFCCR5 chemokine receptor binding
GO:0042056 IDA:UniProtKBFchemoattractant activity
GO:0008009 NAS:UniProtKBFchemokine activity
GO:0046817 IDA:BHF-UCLFchemokine receptor antagonist activity
GO:0042379 IPI:BHF-UCLFchemokine receptor binding
GO:0004435 IDA:UniProtKBFphosphatidylinositol phospholipase C activity
GO:0016004 IDA:UniProtKBFphospholipase activator activity
GO:0042803 IDA:BHF-UCLFprotein homodimerization activity
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0043621 IDA:BHF-UCLFprotein self-association
GO:0030298 IDA:BHF-UCLFreceptor signaling protein tyrosine kinase activator activity
GO:0031584 IDA:BHF-UCLPactivation of phospholipase D activity
GO:0006816 IDA:UniProtKBPcalcium ion transport
GO:0007267 IDA:BHF-UCLPcell-cell signaling
GO:0006874 IDA:UniProtKBPcellular calcium ion homeostasis
GO:0043623 IDA:BHF-UCLPcellular protein complex assembly
GO:0044344 IEP:UniProtKBPcellular response to fibroblast growth factor stimulus
GO:0071346 IEP:UniProtKBPcellular response to interferon-gamma
GO:0071347 IEP:UniProtKBPcellular response to interleukin-1
GO:0071407 IDA:UniProtKBPcellular response to organic cyclic compound
GO:0071356 IEP:UniProtKBPcellular response to tumor necrosis factor
GO:0070098 IDA:UniProtKBPchemokine-mediated signaling pathway
GO:0006935 NAS:UniProtKBPchemotaxis
GO:0002407 TAS:BHF-UCLPdendritic cell chemotaxis
GO:0048245 IDA:BHF-UCLPeosinophil chemotaxis
GO:0006887 IDA:UniProtKBPexocytosis
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0006954 IDA:UniProtKBPinflammatory response
GO:0007159 IDA:BHF-UCLPleukocyte cell-cell adhesion
GO:0031663 IDA:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0048246 TAS:BHF-UCLPmacrophage chemotaxis
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0002548 IC:UniProtKBPmonocyte chemotaxis
GO:0043922 IDA:UniProtKBPnegative regulation by host of viral transcription
GO:0070100 IDA:GOCPnegative regulation of chemokine-mediated signaling pathway
GO:0045744 IDA:UniProtKBPnegative regulation of G-protein coupled receptor protein signaling pathway
GO:2000110 IEA:EnsemblPnegative regulation of macrophage apoptotic process
GO:0070233 IDA:BHF-UCLPnegative regulation of T cell apoptotic process
GO:0045071 IDA:BHF-UCLPnegative regulation of viral genome replication
GO:0042119 IDA:BHF-UCLPneutrophil activation
GO:0050918 IDA:GOCPpositive chemotaxis
GO:0010535 TAS:BHF-UCLPpositive regulation of activation of JAK2 kinase activity
GO:0051928 IDA:UniProtKBPpositive regulation of calcium ion transport
GO:0045785 IDA:BHF-UCLPpositive regulation of cell adhesion
GO:0033634 IDA:BHF-UCLPpositive regulation of cell-cell adhesion mediated by integrin
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0031328 IDA:BHF-UCLPpositive regulation of cellular biosynthetic process
GO:0050679 IEA:EnsemblPpositive regulation of epithelial cell proliferation
GO:0034112 IDA:BHF-UCLPpositive regulation of homotypic cell-cell adhesion
GO:0045089 TAS:BHF-UCLPpositive regulation of innate immune response
GO:0046427 TAS:BHF-UCLPpositive regulation of JAK-STAT cascade
GO:0010759 IDA:BHF-UCLPpositive regulation of macrophage chemotaxis
GO:0090026 IDA:BHF-UCLPpositive regulation of monocyte chemotaxis
GO:2000503 IDA:UniProtKBPpositive regulation of natural killer cell chemotaxis
GO:0014068 IDA:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0042327 IDA:BHF-UCLPpositive regulation of phosphorylation
GO:0061098 IDA:GOCPpositive regulation of protein tyrosine kinase activity
GO:0014911 IDA:BHF-UCLPpositive regulation of smooth muscle cell migration
GO:0048661 IDA:BHF-UCLPpositive regulation of smooth muscle cell proliferation
GO:0070234 IDA:BHF-UCLPpositive regulation of T cell apoptotic process
GO:0010820 IDA:BHF-UCLPpositive regulation of T cell chemotaxis
GO:2000406 IDA:MGIPpositive regulation of T cell migration
GO:0042102 IDA:BHF-UCLPpositive regulation of T cell proliferation
GO:0045948 NAS:BHF-UCLPpositive regulation of translational initiation
GO:0042531 IDA:BHF-UCLPpositive regulation of tyrosine phosphorylation of STAT protein
GO:0045070 TAS:BHF-UCLPpositive regulation of viral genome replication
GO:0043491 IMP:UniProtKBPprotein kinase B signaling
GO:0006468 IDA:GOCPprotein phosphorylation
GO:0051262 IDA:BHF-UCLPprotein tetramerization
GO:0002676 TAS:BHF-UCLPregulation of chronic inflammatory response
GO:0050796 IDA:UniProtKBPregulation of insulin secretion
GO:1901214 IDA:UniProtKBPregulation of neuron death
GO:0050863 IDA:BHF-UCLPregulation of T cell activation
GO:0009636 IDA:UniProtKBPresponse to toxic substance
GO:0009615 TAS:BHF-UCLPresponse to virus
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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