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MGP002788

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 11
Protein EntryCXL11_HUMAN
UniProt IDO14625
SpeciesHuman
Comments
Comment typeDescription
FunctionChemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
InductionBy IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.
InteractionP27487:DPP4; NbExp=2; IntAct=EBI-2871971, EBI-2871277;
Mass SpectrometryMass=8303; Method=MALDI; Range=22-94; Evidence={ECO:0000269|PubMed:10233762};
Sequence CautionSequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityHigh levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Web ResourceName=Wikipedia; Note=CXCL11 entry; URL="http://en.wikipedia.org/wiki/CXCL11";
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