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MGP002827

Record overview

MGPD IDMGP002827
Gene ID6470
SpeciesHomo sapiens (Human)
Gene Nameserine hydroxymethyltransferase 1 (soluble)
Gene Symbol SHMT1
SynonymsSHMT; CSHMT;
Alternate namesserine hydroxymethyltransferase, cytosolic; cytoplasmic serine hydroxymethyltransferase; glycine hydroxymethyltransferase; serine methylase;
Chromosome17
Map Location17p11.2
EC Number2.1.2.1
SummaryThis gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for SHMT1

Proteins

serine hydroxymethyltransferase, cytosolic isoform 1
Refseq ID:NP_004160
Protein GI:22547186
UniProt ID:P34896
mRNA ID:NM_004169
Length:483
RefSeq Status:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRA
LQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIA
GTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSG
LRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
 
serine hydroxymethyltransferase, cytosolic isoform 2
Refseq ID:NP_683718
Protein GI:22547189
UniProt ID:P34896
mRNA ID:NM_148918
Length:444
RefSeq Status:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRA
LQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIA
GTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVAVALKQAMTLEFKVYQHQVVANCRALS
EALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDT
GVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
 
serine hydroxymethyltransferase, cytosolic isoform 3
Refseq ID:NP_001268715
Protein GI:528881075
UniProt ID:P34896
mRNA ID:NM_001281786
Length:345
RefSeq Status:
MGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAA
GVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRAL
SEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSD
TGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
 
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