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MGP002827

UniProt Annotations

Entry Information
Gene Nameserine hydroxymethyltransferase 1 (soluble)
Protein EntryGLYC_HUMAN
UniProt IDP34896
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P34896-1; Sequence=Displayed; Name=2; IsoId=P34896-2; Sequence=VSP_006095; Note=Contains a N6-acetyllysine at position 271.; Name=3; IsoId=P34896-3; Sequence=VSP_006096; Name=4; IsoId=P34896-4; Sequence=VSP_054610; Note=No experimental confirmation available.;
Catalytic Activity5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionInterconversion of serine and glycine.
MiscellaneousIn eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
PathwayOne-carbon metabolism; tetrahydrofolate interconversion.
SimilarityBelongs to the SHMT family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer.
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