MGP Database

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MGP002827

Ontology/Pathway Information

Entrez Gene ID6470
Gene Nameserine hydroxymethyltransferase 1 (soluble)
Gene Symbol SHMT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0016597 IEA:EnsemblFamino acid binding
GO:0004372 IDA:UniProtKBFglycine hydroxymethyltransferase activity
GO:0008732 IEA:EnsemblFL-allo-threonine aldolase activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0030170 IDA:UniProtKBFpyridoxal phosphate binding
GO:0045329 TAS:ReactomePcarnitine biosynthetic process
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0046655 IDA:UniProtKBPfolic acid metabolic process
GO:0019264 IEA:EnsemblPglycine biosynthetic process from serine
GO:0006565 IDA:UniProtKBPL-serine catabolic process
GO:0051289 IEA:EnsemblPprotein homotetramerization
GO:0051262 IDA:UniProtKBPprotein tetramerization
GO:0009113 IDA:UniProtKBPpurine nucleobase biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0035999 IEA:UniProtKB-UniPathwayPtetrahydrofolate interconversion
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_2125Carnitine synthesis
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_11167Metabolism of folate and pterines
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
SMP Pathway Links
SMP IDDescription
SMP007213-Phosphoglycerate dehydrogenase deficiency
SMP00465Carnitine Synthesis
SMP00177Cystathionine Beta-Synthase Deficiency
SMP00179Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242Dimethylglycine Dehydrogenase Deficiency
SMP00484Dimethylglycinuria
SMP00004Glycine and Serine Metabolism
SMP00222Glycine N-methyltransferase Deficiency
SMP00570Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
SMP00485Hyperglycinemia, non-ketotic
SMP00341Hypermethioninemia
SMP00221Methionine Adenosyltransferase Deficiency
SMP00033Methionine Metabolism
SMP00340Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
SMP00223Non Ketotic Hyperglycinemia
SMP00214S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
SMP00244Sarcosinemia
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