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MGP Database

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MGP002828

Ontology/Pathway Information

Entrez Gene ID	6472
Gene Name	serine hydroxymethyltransferase 2 (mitochondrial)
Gene Symbol	SHMT2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0015630	IDA:HPA	C	microtubule cytoskeleton
GO:0005743	IDA:UniProtKB	C	mitochondrial inner membrane
GO:0005758	IEA:Ensembl	C	mitochondrial intermembrane space
GO:0005759	IDA:UniProtKB	C	mitochondrial matrix
GO:0042645	IDA:BHF-UCL	C	mitochondrial nucleoid
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0016597	IEA:Ensembl	F	amino acid binding
GO:0003682	IDA:UniProtKB	F	chromatin binding
GO:0004372	IDA:UniProtKB	F	glycine hydroxymethyltransferase activity
GO:0008732	IEA:Ensembl	F	L-allo-threonine aldolase activity
GO:0030170	IEA:InterPro	F	pyridoxal phosphate binding
GO:0019264	IEA:Ensembl	P	glycine biosynthetic process from serine
GO:0006564	IEA:Ensembl	P	L-serine biosynthetic process
GO:0006730	IDA:UniProtKB	P	one-carbon metabolic process
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0051289	IEA:Ensembl	P	protein homotetramerization
GO:0035999	IEA:UniProtKB-UniPathway	P	tetrahydrofolate interconversion

SMP Pathway Links

SMP ID	Description
SMP00721	3-Phosphoglycerate dehydrogenase deficiency
SMP00179	Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242	Dimethylglycine Dehydrogenase Deficiency
SMP00484	Dimethylglycinuria
SMP00004	Glycine and Serine Metabolism
SMP00485	Hyperglycinemia, non-ketotic
SMP00223	Non Ketotic Hyperglycinemia
SMP00244	Sarcosinemia