MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002828

UniProt Annotations

Entry Information
Gene Nameserine hydroxymethyltransferase 2 (mitochondrial)
Protein EntryGLYM_HUMAN
UniProt IDP34897
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P34897-1; Sequence=Displayed; Name=2; IsoId=P34897-2; Sequence=VSP_043088; Note=No experimental confirmation available.; Name=3; IsoId=P34897-3; Sequence=VSP_043844;
Catalytic Activity5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionContributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. {ECO:0000269|PubMed:21876188}.
MiscellaneousIn eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
PathwayOne-carbon metabolism; tetrahydrofolate interconversion.
SimilarityBelongs to the SHMT family. {ECO:0000305}.
Subcellular LocationMitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane.
SubunitHomotetramer.
  logo