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MGP002832

Record overview

MGPD IDMGP002832
Gene ID6480
SpeciesHomo sapiens (Human)
Gene NameST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Gene Symbol ST6GAL1
SynonymsST6N; SIAT1; ST6GalI;
Alternate namesbeta-galactoside alpha-2,6-sialyltransferase 1; B-cell antigen CD75; CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase);
Chromosome3
Map Location3q27.3
EC Number2.4.99.1
SummaryThis gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
OrthologsView orthologs and multiple alignments for ST6GAL1

Proteins

beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
Refseq ID:NP_775323
Protein GI:27765091
UniProt ID:P15907
mRNA ID:NM_173216
Length:406
RefSeq Status:
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDS
SSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGR
EIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQM
PWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPG
FRTIHC
 
beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
Refseq ID:NP_003023
Protein GI:4506949
UniProt ID:P15907
mRNA ID:NM_003032
Length:406
RefSeq Status:
Protein sequence is identical to GI:27765091 (mRNA isoform)
 
beta-galactoside alpha-2,6-sialyltransferase 1 isoform b
Refseq ID:NP_775324
Protein GI:27765093
UniProt ID:P15907
mRNA ID:NM_173217
Length:175
RefSeq Status:
MNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIM
MTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
 
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