MGP Database

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MGP002832

UniProt Annotations

Entry Information
Gene NameST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Protein EntrySIAT1_HUMAN
UniProt IDP15907
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P15907-1; Sequence=Displayed; Name=2; IsoId=P15907-2; Sequence=VSP_056076; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=530 uM for CMP-NeuAc {ECO:0000269|PubMed:21081508}; Vmax=1.074 pmol/min/ug enzyme {ECO:0000269|PubMed:21081508};
Catalytic ActivityCMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl- 2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine. {ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306}.
Enzyme RegulationInhibited by CTP. {ECO:0000269|PubMed:23999306}.
FunctionTransfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. {ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306}.
PathwayProtein modification; protein glycosylation.
PtmThe HB-6, CDW75, and CD76 differentiation antigens are cell- surface carbohydrate determinants generated by this enzyme.
PtmThe soluble form derives from the membrane form by proteolytic processing.
SimilarityBelongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST6Gal I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_628";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL1";
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