MGP Database

MGP002879

Record overview

MGPD ID	MGP002879
Gene ID	6546
Species	Homo sapiens (Human)
Gene Name	solute carrier family 8 (sodium/calcium exchanger), member 1
Gene Symbol	SLC8A1
Synonyms	NCX1;
Alternate names	sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; solute carrier family 8 member 1;
Chromosome	2
Map Location	2p22.1
Summary	In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Orthologs	View orthologs and multiple alignments for SLC8A1

Proteins

sodium/calcium exchanger 1 isoform A precursor

Refseq ID:	NP_066920
Protein GI:	10863913
UniProt ID:	P32418
mRNA ID:	NM_021097
Length:	973
RefSeq Status:

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAE
MGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNG
WACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

mat_peptide: 36..973
product: Sodium/calcium exchanger 1
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P32418.3)
calculated_mol_wt: 104545
peptide sequence: 
ETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVS
NLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEG
LLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQ
KHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGD
LTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDD
HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMS
EKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNL
ALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSV
TAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGG
ELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sodium/calcium exchanger 1 isoform B precursor

Refseq ID:	NP_001106271
Protein GI:	163914369
UniProt ID:	P32418
mRNA ID:	NM_001112800
Length:	968
RefSeq Status:

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPI
LGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFI
VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG
TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sodium/calcium exchanger 1 isoform C precursor
`sig_peptide: 1..35 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4021 peptide sequence: MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA`

Refseq ID:	NP_001106272
Protein GI:	163914371
UniProt ID:	P32418
mRNA ID:	NM_001112801
Length:	960
RefSeq Status:

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLE
VIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGL
LTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTL
FTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sodium/calcium exchanger 1 isoform D precursor

Refseq ID:	NP_001106273
Protein GI:	163914373
UniProt ID:	P32418
mRNA ID:	NM_001112802
Length:	937
RefSeq Status:

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLA
LVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVT
AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGE
LGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sodium/calcium exchanger 1 isoform E precursor

Refseq ID:	NP_001239553
Protein GI:	357933641
UniProt ID:	P32418
mRNA ID:	NM_001252624
Length:	965
RefSeq Status:

MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKV
SSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGE
HTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSI
LMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLA
FSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA

sig_peptide: 1..35
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4021
peptide sequence: 
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA