MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002879

UniProt Annotations

Entry Information
Gene Namesolute carrier family 8 (sodium/calcium exchanger), member 1
Protein EntryNAC1_HUMAN
UniProt IDP32418
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=NaCa1, NCX1.1; IsoId=P32418-1; Sequence=Displayed; Name=3; Synonyms=NaCa3, NCX1.3; IsoId=P32418-2; Sequence=VSP_003397, VSP_003398, VSP_003400; Name=7; Synonyms=NaCa7, NCX1.7; IsoId=P32418-3; Sequence=VSP_003397, VSP_003398, VSP_003399; Name=10; Synonyms=NaCa10, NCX1.10; IsoId=P32418-4; Sequence=VSP_003397, VSP_003398; Name=5; IsoId=P32418-5; Sequence=VSP_003399;
Enzyme RegulationBy ATP.
FunctionRapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. {ECO:0000269|PubMed:1476165}.
Sequence CautionSequence=AAH98308.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. {ECO:0000305}.
SimilarityContains 2 Calx-beta domains. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. {ECO:0000269|PubMed:1476165}.
  logo