MGP Database

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MGP002879

Ontology/Pathway Information

Entrez Gene ID6546
Gene Namesolute carrier family 8 (sodium/calcium exchanger), member 1
Gene Symbol SLC8A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016323 IEA:EnsemblCbasolateral plasma membrane
GO:0005887 IDA:BHF-UCLCintegral component of plasma membrane
GO:0014704 ISS:BHF-UCLCintercalated disc
GO:0005886 TAS:BHF-UCLCplasma membrane
GO:0042383 ISS:BHF-UCLCsarcolemma
GO:0030315 ISS:BHF-UCLCT-tubule
GO:0030018 ISS:BHF-UCLCZ disc
GO:0030506 IPI:BHF-UCLFankyrin binding
GO:0005432 IDA:BHF-UCLFcalcium:sodium antiporter activity
GO:0008092 IDA:BHF-UCLFcytoskeletal protein binding
GO:0044325 ISS:BHF-UCLFion channel binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0007596 TAS:ReactomePblood coagulation
GO:1901660 IDA:BHF-UCLPcalcium ion export
GO:0055074 ISS:BHF-UCLPcalcium ion homeostasis
GO:0070509 IDA:BHF-UCLPcalcium ion import
GO:0060402 ISS:BHF-UCLPcalcium ion transport into cytosol
GO:0055013 ISS:BHF-UCLPcardiac muscle cell development
GO:0060048 TAS:BHF-UCLPcardiac muscle contraction
GO:0086064 ISS:BHF-UCLPcell communication by electrical coupling involved in cardiac conduction
GO:0071313 ISS:BHF-UCLPcellular response to caffeine
GO:0034614 IDA:BHF-UCLPcellular response to reactive oxygen species
GO:0006883 IDA:BHF-UCLPcellular sodium ion homeostasis
GO:0060401 TAS:BHF-UCLPcytosolic calcium ion transport
GO:0035050 IEA:EnsemblPembryonic heart tube development
GO:0001892 IEA:EnsemblPembryonic placenta development
GO:0003007 IEA:EnsemblPheart morphogenesis
GO:0006811 TAS:ReactomePion transport
GO:0086012 TAS:BHF-UCLPmembrane depolarization during cardiac muscle cell action potential
GO:0006936 TAS:ProtIncPmuscle contraction
GO:0048747 IEA:EnsemblPmuscle fiber development
GO:0051481 ISS:BHF-UCLPnegative regulation of cytosolic calcium ion concentration
GO:0098735 IMP:BHF-UCLPpositive regulation of the force of heart contraction
GO:0009791 IEA:EnsemblPpost-embryonic development
GO:0010882 TAS:BHF-UCLPregulation of cardiac muscle contraction by calcium ion signaling
GO:0010881 ISS:BHF-UCLPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010649 TAS:BHF-UCLPregulation of cell communication by electrical coupling
GO:0002027 ISS:BHF-UCLPregulation of heart rate
GO:0002026 ISS:BHF-UCLPregulation of the force of heart contraction
GO:0055119 TAS:BHF-UCLPrelaxation of cardiac muscle
GO:0044557 ISS:BHF-UCLPrelaxation of smooth muscle
GO:0035994 IMP:BHF-UCLPresponse to muscle stretch
GO:0071436 IDA:BHF-UCLPsodium ion export
GO:0097369 IDA:BHF-UCLPsodium ion import
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0014829 ISS:BHF-UCLPvascular smooth muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_604Hemostasis
REACT_23905Platelet calcium homeostasis
REACT_23876Platelet homeostasis
REACT_23765Reduction of cytosolic Ca++ levels
REACT_19118SLC-mediated transmembrane transport
REACT_19320Sodium/Calcium exchangers
REACT_15518Transmembrane transport of small molecules
REACT_19397Transport of inorganic cations/anions and amino acids/oligopeptides
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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