MGP Database

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MGP002936

Record overview

MGPD IDMGP002936
Gene ID6622
SpeciesHomo sapiens (Human)
Gene Namesynuclein, alpha (non A4 component of amyloid precursor)
Gene Symbol SNCA
SynonymsPD1; NACP; PARK1; PARK4;
Alternate namesalpha-synuclein; non A-beta component of AD amyloid; synuclein alpha-140;
Chromosome4
Map Location4q21
SummaryAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for SNCA

Proteins

alpha-synuclein isoform NACP112
Refseq ID:NP_009292
Protein GI:6806898
UniProt ID:P37840
mRNA ID:NM_007308
Length:112
RefSeq Status:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQL
GKEGYQDYEPEA
 
alpha-synuclein isoform NACP140
Refseq ID:NP_001139526
Protein GI:225690602
UniProt ID:P37840
mRNA ID:NM_001146054
Length:140
RefSeq Status:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQL
GKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
 
alpha-synuclein isoform NACP140
Refseq ID:NP_000336
Protein GI:4507109
UniProt ID:P37840
mRNA ID:NM_000345
Length:140
RefSeq Status:
Protein sequence is identical to GI:225690602 (mRNA isoform)
 
alpha-synuclein isoform NACP140
Refseq ID:NP_001139527
Protein GI:225690604
UniProt ID:P37840
mRNA ID:NM_001146055
Length:140
RefSeq Status:
Protein sequence is identical to GI:225690602 (mRNA isoform)
 
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