MGP Database

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MGP002936

Ontology/Pathway Information

Entrez Gene ID6622
Gene Namesynuclein, alpha (non A4 component of amyloid precursor)
Gene Symbol SNCA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0015629 IDA:UniProtKBCactin cytoskeleton
GO:0030424 IDA:UniProtKBCaxon
GO:0005938 IDA:UniProtKBCcell cortex
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0030659 IEA:EnsemblCcytoplasmic vesicle membrane
GO:0005829 IDA:UniProtKBCcytosol
GO:0005576 TAS:ReactomeCextracellular region
GO:0043205 IDA:UniProtKBCfibril
GO:0005794 IEA:EnsemblCGolgi apparatus
GO:0030426 IDA:UniProtKBCgrowth cone
GO:0016234 IDA:UniProtKBCinclusion body
GO:0005764 TAS:ParkinsonsUK-UCLClysosome
GO:0005739 TAS:ParkinsonsUK-UCLCmitochondrion
GO:0005640 IEA:EnsemblCnuclear outer membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005840 IEA:EnsemblCribosome
GO:0005791 IEA:EnsemblCrough endoplasmic reticulum
GO:0008021 IEA:EnsemblCsynaptic vesicle
GO:0043195 IEA:EnsemblCterminal bouton
GO:0043014 IPI:UniProtKBFalpha-tubulin binding
GO:0005509 IDA:UniProtKBFcalcium ion binding
GO:0005507 IDA:UniProtKBFcopper ion binding
GO:0043027 IDA:UniProtKBFcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0045502 IPI:UniProtKBFdynein binding
GO:0008198 IDA:UniProtKBFferrous iron binding
GO:0042393 IDA:UniProtKBFhistone binding
GO:0030544 IPI:UniProtKBFHsp70 protein binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0019894 IPI:UniProtKBFkinesin binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0016491 IDA:UniProtKBFoxidoreductase activity
GO:0005543 IDA:ParkinsonsUK-UCLFphospholipid binding
GO:0051219 IDA:BHF-UCLFphosphoprotein binding
GO:0048156 IDA:UniProtKBFtau protein binding
GO:0044212 TAS:ParkinsonsUK-UCLFtranscription regulatory region DNA binding
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0006919 IDA:BHF-UCLPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008344 IEA:EnsemblPadult locomotory behavior
GO:0007568 IEA:EnsemblPaging
GO:0048148 IEA:EnsemblPbehavioral response to cocaine
GO:0071280 IDA:UniProtKBPcellular response to copper ion
GO:0071872 TAS:UniProtKBPcellular response to epinephrine stimulus
GO:0044344 IEA:EnsemblPcellular response to fibroblast growth factor stimulus
GO:0034599 IC:ParkinsonsUK-UCLPcellular response to oxidative stress
GO:0042416 TAS:UniProtKBPdopamine biosynthetic process
GO:0051583 TAS:UniProtKBPdopamine uptake involved in synaptic transmission
GO:0043206 TAS:UniProtKBPextracellular fibril organization
GO:0006631 IEA:EnsemblPfatty acid metabolic process
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0001774 TAS:ParkinsonsUK-UCLPmicroglial cell activation
GO:0042775 IEA:EnsemblPmitochondrial ATP synthesis coupled electron transport
GO:0007006 IEA:EnsemblPmitochondrial membrane organization
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0043154 IMP:UniProtKBPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045963 IEA:EnsemblPnegative regulation of dopamine metabolic process
GO:0051585 IDA:UniProtKBPnegative regulation of dopamine uptake involved in synaptic transmission
GO:0045920 IMP:UniProtKBPnegative regulation of exocytosis
GO:0035067 IDA:UniProtKBPnegative regulation of histone acetylation
GO:0031115 IDA:BHF-UCLPnegative regulation of microtubule polymerization
GO:1902957 TAS:ParkinsonsUK-UCLPnegative regulation of mitochondrial electron transport, NADH to ubiquinone
GO:0032769 IDA:BHF-UCLPnegative regulation of monooxygenase activity
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0051622 IDA:UniProtKBPnegative regulation of norepinephrine uptake
GO:0010642 IDA:UniProtKBPnegative regulation of platelet-derived growth factor receptor signaling pathway
GO:0001933 IEA:EnsemblPnegative regulation of protein phosphorylation
GO:0051612 IDA:UniProtKBPnegative regulation of serotonin uptake
GO:0070495 IDA:UniProtKBPnegative regulation of thrombin receptor signaling pathway
GO:0000122 TAS:ParkinsonsUK-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0032410 IDA:UniProtKBPnegative regulation of transporter activity
GO:0006638 IEA:EnsemblPneutral lipid metabolic process
GO:0055114 IDA:UniProtKBPoxidation-reduction process
GO:0006644 IEA:EnsemblPphospholipid metabolic process
GO:0043065 TAS:ParkinsonsUK-UCLPpositive regulation of apoptotic process
GO:0045807 IDA:UniProtKBPpositive regulation of endocytosis
GO:1903284 IDA:ParkinsonsUK-UCLPpositive regulation of glutathione peroxidase activity
GO:1903285 IDA:ParkinsonsUK-UCLPpositive regulation of hydrogen peroxide catabolic process
GO:0060732 IDA:UniProtKBPpositive regulation of inositol phosphate biosynthetic process
GO:0001956 IEA:EnsemblPpositive regulation of neurotransmitter secretion
GO:0033138 ISS:BHF-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0071902 IDA:BHF-UCLPpositive regulation of protein serine/threonine kinase activity
GO:0001921 IDA:UniProtKBPpositive regulation of receptor recycling
GO:0051281 IDA:UniProtKBPpositive regulation of release of sequestered calcium ion into cytosol
GO:0031648 IDA:UniProtKBPprotein destabilization
GO:0031623 IDA:UniProtKBPreceptor internalization
GO:0050812 IEA:EnsemblPregulation of acyl-CoA biosynthetic process
GO:0014059 TAS:UniProtKBPregulation of dopamine secretion
GO:0060079 IEA:EnsemblPregulation of excitatory postsynaptic membrane potential
GO:0014048 IEA:EnsemblPregulation of glutamate secretion
GO:0040012 IEA:EnsemblPregulation of locomotion
GO:0048169 IEA:EnsemblPregulation of long-term neuronal synaptic plasticity
GO:0043030 IEA:EnsemblPregulation of macrophage activation
GO:0010517 IDA:UniProtKBPregulation of phospholipase activity
GO:1903426 TAS:ParkinsonsUK-UCLPregulation of reactive oxygen species biosynthetic process
GO:1903421 TAS:ParkinsonsUK-UCLPregulation of synaptic vesicle recycling
GO:0042493 IEA:EnsemblPresponse to drug
GO:0034341 IDA:UniProtKBPresponse to interferon-gamma
GO:0070555 IDA:UniProtKBPresponse to interleukin-1
GO:0010040 IDA:UniProtKBPresponse to iron(II) ion
GO:0032496 IDA:UniProtKBPresponse to lipopolysaccharide
GO:0032026 IDA:UniProtKBPresponse to magnesium ion
GO:0050808 IEA:EnsemblPsynapse organization
GO:0048488 ISS:UniProtKBPsynaptic vesicle endocytosis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75925Amyloids
REACT_116125Disease
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