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MGP002951

Record overview

MGPD IDMGP002951
Gene ID6648
SpeciesHomo sapiens (Human)
Gene Namesuperoxide dismutase 2, mitochondrial
Gene Symbol SOD2
SynonymsIPOB; MNSOD; MVCD6;
Alternate namessuperoxide dismutase [Mn], mitochondrial; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; mangano-superoxide dismutase;
Chromosome6
Map Location6q25.3
EC Number1.15.1.1
SummaryThis gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOD2

Proteins

superoxide dismutase [Mn], mitochondrial isoform A precursor
Refseq ID:NP_000627
Protein GI:67782305
UniProt ID:P04179
mRNA ID:NM_000636
Length:222
RefSeq Status:
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSI
FWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDY
LKAIWNVINWENVTERYMACKK
 
sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..183
product: superoxide dismutase [Mn], mitochondrial isoform B
calculated_mol_wt: 18178
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAA
CPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..222
product: superoxide dismutase [Mn], mitochondrial isoform A
calculated_mol_wt: 22204
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRD
FGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..222
product: superoxide dismutase [Mn], mitochondrial isoform A
calculated_mol_wt: 22204
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRD
FGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
 
superoxide dismutase [Mn], mitochondrial isoform A precursor
Refseq ID:NP_001019636
Protein GI:67782307
UniProt ID:P04179
mRNA ID:NM_001024465
Length:222
RefSeq Status:
Protein sequence is identical to GI:67782305 (mRNA isoform)
 
sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..183
product: superoxide dismutase [Mn], mitochondrial isoform B
calculated_mol_wt: 18178
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAA
CPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..222
product: superoxide dismutase [Mn], mitochondrial isoform A
calculated_mol_wt: 22204
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRD
FGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
 
superoxide dismutase [Mn], mitochondrial isoform B precursor
Refseq ID:NP_001019637
Protein GI:67782309
UniProt ID:P04179
mRNA ID:NM_001024466
Length:183
RefSeq Status:
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGELLEAIKRDFGSFDKFKEKLTAAS
VGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
 
sig_peptide: 1..24
calculated_mol_wt: 2564
peptide sequence: 
MLSRAVCGTSRQLAPVLGYLGSRQ

mat_peptide: 25..183
product: superoxide dismutase [Mn], mitochondrial isoform B
calculated_mol_wt: 18178
peptide sequence: 
KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAA
CPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
 
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