MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002951

UniProt Annotations

Entry Information
Gene Namesuperoxide dismutase 2, mitochondrial
Protein EntrySODM_HUMAN
UniProt IDP04179
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P04179-1; Sequence=Displayed; Name=2; IsoId=P04179-2; Sequence=VSP_042558; Note=No experimental confirmation available.; Name=3; IsoId=P04179-3; Sequence=VSP_053762; Note=No experimental confirmation available.; Name=4; IsoId=P04179-4; Sequence=VSP_053761; Note=No experimental confirmation available.;
Catalytic Activity2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.;
DiseaseMicrovascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionDestroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}.
InductionExpression is regulated by KRIT1. {ECO:0000269|PubMed:20668652}.
InteractionSelf; NbExp=2; IntAct=EBI-716989, EBI-716989;
PtmAcetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity). {ECO:0000250}.
PtmNitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. {ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855}.
SimilarityBelongs to the iron/manganese superoxide dismutase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer. {ECO:0000269|PubMed:19265433}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sod2/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2";
Web ResourceName=Wikipedia; Note=Superoxide dismutase entry; URL="http://en.wikipedia.org/wiki/Superoxide_dismutase";
  logo