MGP Database

MGP002951

Ontology/Pathway Information

Entrez Gene ID	6648
Gene Name	superoxide dismutase 2, mitochondrial
Gene Symbol	SOD2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005743	IEA:Ensembl	C	mitochondrial inner membrane
GO:0005759	TAS:BHF-UCL	C	mitochondrial matrix
GO:0042645	IEA:Ensembl	C	mitochondrial nucleoid
GO:0005739	IDA:BHF-UCL	C	mitochondrion
GO:0003677	IEA:Ensembl	F	DNA binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0030145	IDA:UniProtKB	F	manganese ion binding
GO:0019825	IEA:Ensembl	F	oxygen binding
GO:0004784	IDA:UniProtKB	F	superoxide dismutase activity
GO:0001315	IMP:UniProtKB	P	age-dependent response to reactive oxygen species
GO:0071361	IEA:Ensembl	P	cellular response to ethanol
GO:0003032	IEA:Ensembl	P	detection of oxygen
GO:0048773	IEA:Ensembl	P	erythrophore differentiation
GO:0006749	IEA:Ensembl	P	glutathione metabolic process
GO:0007507	IEA:Ensembl	P	heart development
GO:0030097	IEA:Ensembl	P	hemopoiesis
GO:0050665	IEA:Ensembl	P	hydrogen peroxide biosynthetic process
GO:0008630	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0055072	IEA:Ensembl	P	iron ion homeostasis
GO:0001889	IEA:Ensembl	P	liver development
GO:0007626	IEA:Ensembl	P	locomotory behavior
GO:0008285	IMP:BHF-UCL	P	negative regulation of cell proliferation
GO:0045599	IEA:Ensembl	P	negative regulation of fat cell differentiation
GO:0048147	IEA:Ensembl	P	negative regulation of fibroblast proliferation
GO:0043524	IGI:BHF-UCL	P	negative regulation of neuron apoptotic process
GO:1902176	IMP:BHF-UCL	P	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0048666	IEA:Ensembl	P	neuron development
GO:0032364	IMP:BHF-UCL	P	oxygen homeostasis
GO:0045429	IEA:Ensembl	P	positive regulation of nitric oxide biosynthetic process
GO:0009791	IEA:Ensembl	P	post-embryonic development
GO:0051289	IPI:UniProtKB	P	protein homotetramerization
GO:0008217	ISS:BHF-UCL	P	regulation of blood pressure
GO:0050790	IEA:Ensembl	P	regulation of catalytic activity
GO:0051881	IEA:Ensembl	P	regulation of mitochondrial membrane potential
GO:0006357	IMP:UniProtKB	P	regulation of transcription from RNA polymerase II promoter
GO:0001836	ISS:BHF-UCL	P	release of cytochrome c from mitochondria
GO:0019430	IMP:BHF-UCL	P	removal of superoxide radicals
GO:0022904	IEA:Ensembl	P	respiratory electron transport chain
GO:0014823	IEA:Ensembl	P	response to activity
GO:0048678	IEA:Ensembl	P	response to axon injury
GO:0046686	IEA:Ensembl	P	response to cadmium ion
GO:0009409	IEA:Ensembl	P	response to cold
GO:0042493	IEA:Ensembl	P	response to drug
GO:0051602	IEA:Ensembl	P	response to electrical stimulus
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0055093	IEA:Ensembl	P	response to hyperoxia
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0035902	IEA:Ensembl	P	response to immobilization stress
GO:0035900	IEA:Ensembl	P	response to isolation stress
GO:0033591	IEA:Ensembl	P	response to L-ascorbic acid
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0071000	IEA:Ensembl	P	response to magnetism
GO:0010042	IEA:Ensembl	P	response to manganese ion
GO:0010269	IEA:Ensembl	P	response to selenium ion
GO:0034021	IEA:Ensembl	P	response to silicon dioxide
GO:0000303	IMP:BHF-UCL	P	response to superoxide
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0042554	IEA:Ensembl	P	superoxide anion generation
GO:0006801	IDA:UniProtKB	P	superoxide metabolic process
GO:0003069	ISS:BHF-UCL	P	vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_120956	Cellular responses to stress
REACT_264249	Detoxification of Reactive Oxygen Species

SMP Pathway Links

SMP ID	Description
SMP00468	Degradation of Superoxides