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MGP002961

Record overview

MGPD IDMGP002961
Gene ID6678
SpeciesHomo sapiens (Human)
Gene Namesecreted protein, acidic, cysteine-rich (osteonectin)
Gene Symbol SPARC
SynonymsON;
Alternate namesSPARC; BM-40; basement-membrane protein 40; cysteine-rich protein; osteonectin; secreted protein acidic and rich in cysteine;
Chromosome5
Map Location5q31.3-q32
SummaryThis gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for SPARC

Proteins

SPARC precursor
Refseq ID:NP_003109
Protein GI:4507171
UniProt ID:P09486
mRNA ID:NM_003118
Length:303
RefSeq Status:
MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTS
CPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIH
ENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKD
LVI
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1952
peptide sequence: 
MRAWIFFLLCLAGRALA

mat_peptide: 18..303
product: SPARC
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P09486.1)
calculated_mol_wt: 32698
peptide sequence: 
APQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNK
TFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLA
RDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI
 
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