MGP Database

MGP002961

Ontology/Pathway Information

Entrez Gene ID	6678
Gene Name	secreted protein, acidic, cysteine-rich (osteonectin)
Gene Symbol	SPARC
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005604	IEA:UniProtKB-SubCell	C	basement membrane
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0071682	TAS:Reactome	C	endocytic vesicle lumen
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0016363	IDA:UniProtKB	C	nuclear matrix
GO:0031091	IDA:UniProtKB	C	platelet alpha granule
GO:0031093	TAS:Reactome	C	platelet alpha granule lumen
GO:0031092	IDA:UniProtKB	C	platelet alpha granule membrane
GO:0005509	IDA:UniProtKB	F	calcium ion binding
GO:0005518	IDA:UniProtKB	F	collagen binding
GO:0050840	IEA:Ensembl	F	extracellular matrix binding
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0060348	IEA:Ensembl	P	bone development
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0007507	IEA:Ensembl	P	heart development
GO:0048839	IEA:Ensembl	P	inner ear development
GO:0030324	IEA:Ensembl	P	lung development
GO:0016525	IDA:UniProtKB	P	negative regulation of angiogenesis
GO:0001937	IDA:UniProtKB	P	negative regulation of endothelial cell proliferation
GO:0001503	IEA:Ensembl	P	ossification
GO:0030168	TAS:Reactome	P	platelet activation
GO:0002576	TAS:Reactome	P	platelet degranulation
GO:0010595	IDA:UniProtKB	P	positive regulation of endothelial cell migration
GO:0022604	IDA:UniProtKB	P	regulation of cell morphogenesis
GO:0046686	IEA:Ensembl	P	response to cadmium ion
GO:0051592	IEA:Ensembl	P	response to calcium ion
GO:0051591	IEA:Ensembl	P	response to cAMP
GO:0034097	IEA:Ensembl	P	response to cytokine
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0009629	IEA:Ensembl	P	response to gravity
GO:0033591	IEA:Ensembl	P	response to L-ascorbic acid
GO:0010288	IEA:Ensembl	P	response to lead ion
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0007165	IEA:InterPro	P	signal transduction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_160300	Binding and Uptake of Ligands by Scavenger Receptors
REACT_163906	ECM proteoglycans
REACT_118779	Extracellular matrix organization
REACT_604	Hemostasis
REACT_798	Platelet activation, signaling and aggregation
REACT_318	Platelet degranulation
REACT_1280	Response to elevated platelet cytosolic Ca2+
REACT_164002	Scavenging by Class H Receptors