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MGP002961

UniProt Annotations

Entry Information
Gene Namesecreted protein, acidic, cysteine-rich (osteonectin)
Protein EntrySPRC_HUMAN
UniProt IDP09486
SpeciesHuman
Comments
Comment typeDescription
Developmental StageExpressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
InteractionQ2TV77:faf (xeno); NbExp=4; IntAct=EBI-2800983, EBI-6405263;
Sequence CautionSequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};
SimilarityBelongs to the SPARC family. {ECO:0000305}.
SimilarityContains 1 EF-hand domain. {ECO:0000305}.
SimilarityContains 1 follistatin-like domain. {ECO:0000305}.
SimilarityContains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule:PRU00798}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.
Web ResourceName=Wikipedia; Note=Osteonectin entry; URL="http://en.wikipedia.org/wiki/Osteonectin";
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