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MGP003076

UniProt Annotations

Entry Information
Gene Namethromboxane A2 receptor
Protein EntryTA2R_HUMAN
UniProt IDP21731
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=P21731-3; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P21731-2; Sequence=VSP_001925; Note=Ref.2 (AAA58957) sequence differs from that shown due to frameshifts in positions 330 and 386. {ECO:0000305};
DiseaseBleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269|PubMed:7929844}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionReceptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.
InteractionQ13162:PRDX4; NbExp=3; IntAct=EBI-2625082, EBI-2211957;
Sequence CautionSequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression. {ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:19464661}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tbxa2r/";
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